Abstract | BACKGROUND: METHODS:
Non-small cell lung cancer (NSCLC) patients with the EGFR T790 M mutation were orally administered avitinib (150-300 mg) twice daily for cycles of 28 continuous days. Blood and cerebrospinal fluid samples (2 ml each) were collected on day 29 in available patients with brain metastases, and the tumor response was assessed. RESULTS: Sixteen NSCLC patients were included, of whom nine (60.0%) achieved a partial response, and five (33.3%) achieved stable disease. Median progression-free survival (PFS) and overall survival were 247 days (95% confidence interval (CI): 154.8-339.2) and 536 days (95%CI: 363.6-708.4), respectively. The median intracranial PFS of seven brain metastases patients was 142 days (95% CI 31.1-252.9). Blood and cerebrospinal fluid analysis of five brain metastases patients showed the BBB penetration rate to be 0.046%-0.146%. The most frequent adverse events were mild and reversible hepatic transaminases elevating (10/16, 62.5%) and diarrhea (4/16, 25.0%). CONCLUSIONS:
Avitinib is well tolerated and efficacious in T790M-positive patients. Its penetrability to the BBB is weak, but it showed good control of asymptomatic brain metastases. Further studies are proceeding.
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Authors | Hanping Wang, Li Zhang, Pei Hu, Xin Zheng, Xiaoyan Si, Xiaotong Zhang, Mengzhao Wang |
Journal | Lung cancer (Amsterdam, Netherlands)
(Lung Cancer)
Vol. 122
Pg. 1-6
(08 2018)
ISSN: 1872-8332 [Electronic] Ireland |
PMID | 30032814
(Publication Type: Clinical Trial, Phase I, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 Elsevier B.V. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Pyrimidines
- abivertinib
- EGFR protein, human
- ErbB Receptors
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Topics |
- Adult
- Aged
- Antineoplastic Agents
(therapeutic use)
- Blood-Brain Barrier
(drug effects)
- Brain Neoplasms
(pathology)
- Carcinoma, Non-Small-Cell Lung
(drug therapy, mortality, pathology)
- ErbB Receptors
(antagonists & inhibitors, genetics)
- Female
- Humans
- Lung Neoplasms
(drug therapy, mortality, pathology)
- Male
- Middle Aged
- Mutation
(genetics)
- Pyrimidines
(therapeutic use)
- Survival Analysis
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