Near Infrared Light Triggered Cucurbit[7]uril-Stabilized Gold Nanostars as a Supramolecular Nanoplatform for Combination Treatment of Cancer.

Abstract	Developing a spatiotemporal-controlled platform with feasible synthesis and multifunctionality is highly desirable in the field of nanomedicine. Here, we present a near-infrared (NIR)-light-triggered approach to control the supramolecular assembly system for drug release and achieve synergistic chemo-photothermal therapy for cancer. A cucurbit[7]uril (CB[7]) stabilized gold nanostar (GNS) platform is designed to encapsulate the anticancer drug camptothecin (CPT) via host-guest chemistry. Importantly, CB[7] behaves not only as a surfactant to improve the stability of GNS in the aqueous solution but also as the cage for intermolecular assembly of CPT molecules. Moreover, without the competitive complexation, the drug release could be stimulated under NIR light irradiation. Synergistic treatment of cancer can be achieved by combining chemotherapy with the photothermal effect of GNS. This work develops a NIR-light-triggered cucurbituril-based drug-release approach that opens the door for remote control of drug release in the supramolecular assembly system.
Authors	Peng Xu, Qishuai Feng, Xiran Yang, Simin Liu, Chang Xu, Liqun Huang, Mengwei Chen, Feng Liang, Yu Cheng
Journal	Bioconjugate chemistry (Bioconjug Chem) Vol. 29 Issue 8 Pg. 2855-2866 (08 15 2018) ISSN: 1520-4812 [Electronic] United States
PMID	30025449 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents Bridged-Ring Compounds Imidazoles cucurbit(7)uril Gold Camptothecin
Topics	Animals Antineoplastic Agents (chemistry, pharmacokinetics, therapeutic use) Bridged-Ring Compounds (chemistry, therapeutic use) Camptothecin (chemistry, pharmacokinetics, therapeutic use) Combined Modality Therapy Gold (chemistry) Humans Hyperthermia, Induced (methods) Imidazoles (chemistry, therapeutic use) Infrared Rays MCF-7 Cells Mice Microscopy, Confocal Microscopy, Electron, Transmission Nanostructures (chemistry) Neoplasms (drug therapy, therapy) Photochemotherapy (methods) Spectrometry, Fluorescence Tissue Distribution Xenograft Model Antitumor Assays

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