Abstract | Background: Objective: Methods: SEDULC was a randomized, double-blind, crossover study. Nondiabetic adults [mean age 31 y, 44% men, body mass index (BMI; kg/m²) 19-29] who did not consume high-intensity sweeteners were randomized 1:1 to drink 1 of the 2 carbonated beverages, 2 cans (330 mL each)/d, for 12 wk. After a 4-wk washout period, participants were switched to the opposite beverage for 12 wk. The primary outcome tested was the change in insulin sensitivity as assessed by the Matsuda Insulin Sensitivity Index (MISI) after an oral glucose load. Secondary outcomes were indexes of insulin secretion. Results: Sixty individuals were enrolled and 50 completed the study (28 nonoverweight and 22 overweight participants). The change in MISI from baseline did not significantly differ between beverages and noninferiority was demonstrated (difference = -0.23; 95% CI: -1.31, 0.85; P < 0.0001). The change in insulinogenic (means ± SEMs: 0.23 ± 0.14 for HISB compared with 0.08 ± 0.1 for UB) and disposition indexes (2.70 ± 0.99 for HISB compared with 1.62 ± 0.90 for UB) did not differ, and no differences in insulin secretion estimates were confirmed by the Stumvoll indexes. Consuming the high-intensity sweeteners did not affect body weight, self-reported dietary consumption, or self-reported physical activity. Conclusions: These findings suggest that the daily consumption of 2 cans of a beverage containing aspartame and acesulfame K over 12 wk has no significant effect on insulin sensitivity and secretion in nondiabetic adults. This trial was registered at clinicaltrials.gov as NCT02031497.
|
Authors | Fabrice Bonnet, Aude Tavenard, Maxime Esvan, Bruno Laviolle, Mélanie Viltard, Eve M Lepicard, Fabrice Lainé |
Journal | The Journal of nutrition
(J Nutr)
Vol. 148
Issue 8
Pg. 1293-1299
(08 01 2018)
ISSN: 1541-6100 [Electronic] United States |
PMID | 29982723
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Insulin
- Non-Nutritive Sweeteners
- Thiazines
- Glucose
- acetosulfame
- Aspartame
|
Topics |
- Adult
- Aspartame
(pharmacology)
- Carbonated Beverages
- Cross-Over Studies
- Diabetes Mellitus
(metabolism)
- Diet
- Double-Blind Method
- Feeding Behavior
- Female
- Glucose
(administration & dosage)
- Humans
- Insulin
(metabolism)
- Insulin Resistance
- Male
- Non-Nutritive Sweeteners
(pharmacology)
- Reference Values
- Thiazines
(pharmacology)
|