Abstract | BACKGROUND: METHODS: Twenty-seven patients with schizophrenia and comorbid depression were treated with AGO in addition to stable doses of antipsychotic drugs. Cognitive abilities were assessed with the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB) at study entry and after 12 weeks of AGO treatment after the intention-to-treat principle. RESULTS: We observed statistically significant yet clinically negligible increases of the MCCB composite score and the reasoning/problem solving subscore. Patients with unimpaired sleep at baseline showed greater improvements over time than those with sleep disturbances. Changes on the MCCB were not correlated with other psychometric variables. CONCLUSIONS: Despite statistically significant, cognitive improvements after 12 weeks of AGO treatment were clinically irrelevant. Our findings may be limited by baseline properties of the study sample and the study design. In particular, lacking a control group, it cannot be ruled out that improvements were unrelated to AGO treatment. That is why randomized controlled trials are needed to validate the relevance of AGO as a cognitive enhancer in schizophrenia.
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Authors | Susanne Englisch, Hanna Sophie Jung, Sarah Eisenacher, Antje Lewien, Anna Becker, Ulrike Nowak, Hanna Braun, Jascha Thiem, Andreas Meyer-Lindenberg, Mathias Zink |
Journal | Journal of clinical psychopharmacology
(J Clin Psychopharmacol)
Vol. 38
Issue 4
Pg. 357-361
(Aug 2018)
ISSN: 1533-712X [Electronic] United States |
PMID | 29912792
(Publication Type: Journal Article)
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Chemical References |
- Acetamides
- Antipsychotic Agents
- agomelatine
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Topics |
- Acetamides
(administration & dosage, adverse effects, therapeutic use)
- Adult
- Antipsychotic Agents
(administration & dosage, adverse effects, therapeutic use)
- Cognitive Dysfunction
(chemically induced)
- Depression
(complications)
- Drug Therapy, Combination
- Female
- Humans
- Male
- Neuropsychological Tests
- Schizophrenia
(complications, drug therapy)
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