Pro-Gastrin Releasing Peptide: A New Serum Marker for Endometrioid Adenocarcinoma.

Abstract

BACKGROUND:

Gastrin-releasing peptide (GRP) is thought to play a role in the metastatic process of various malignancies. The more stable precursor of GRP, pro-GRP (ProGRP), has been shown to be secreted by neuroendocrine tumors. This study was designed to assess the validity of ProGRP as a diagnostic marker in endometrioid adenocarcinomas (EAs) of the endometrium.

METHODS:

Thirty-seven patients with a diagnosis of EA, 23 patients with endometrial hyperplasia, and 32 age-matched controls with normal endometrial histology were recruited for this study. Serum ProGRP and cancer antigen 125 (CA125) values were compared between groups.

RESULTS:

Median serum ProGRP levels were significantly higher in the cancer group compared to corresponding levels in both the hyperplasia and control groups (p = 0.008 and p < 0.001 respectively; endometrial cancer: 27.5 pg/mL; hyperplasia: 16.1 pg/mL; controls: 12.9 pg/mL). Age and endometrial thickness were positively correlated with ProGRP levels (r = 0.322, p = 0.006 and r = 0.269, p = 0.023, respectively). Receiver Operating Characteristic curve analyses for EA revealed a threshold of 20.81 pg/mL, with a sensitivity of 60.7% and specificity of 81.4%, positive predictive value of 68% and negative predictive value of 76.1%.

CONCLUSION:

Significantly higher ProGRP levels were observed in patients with EA than in controls. Serum ProGRP has good diagnostic sensitivity and specificity for EA.

• Authors: Mine Kiseli, Gamze Sinem Caglar, Asli Yarci Gursoy, Tolga Tasci, Tuba Candar, Egemen Akincioglu, Emre Goksan Pabuccu, Nurettin Boran, Gokhan Tulunay, Haldun Umudum
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 83 Issue 6 Pg. 540-545 ( 2018) ISSN: 1423-002X [Electronic] Switzerland
• PMID: 29898448 (Publication Type: Journal Article, Validation Study)
• Copyright: © 2018 S. Karger AG, Basel.

Chemical References

• Biomarkers, Tumor
• CA-125 Antigen
• MUC16 protein, human
• Membrane Proteins
• Peptide Fragments
• Recombinant Proteins
• pro-gastrin-releasing peptide (31-98)

Topics

• Adult
• Aged
• Biomarkers, Tumor (blood)
• CA-125 Antigen (blood)
• Carcinoma, Endometrioid (blood)
• Case-Control Studies
• Endometrial Neoplasms (blood)
• Endometrium (pathology)
• Female
• Humans
• Membrane Proteins (blood)
• Middle Aged
• Peptide Fragments (blood)
• Prospective Studies
• Recombinant Proteins (blood)
• Sensitivity and Specificity