HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters.

Abstract
Rift Valley fever virus (RVFV) is a mosquito-borne pathogen endemic to sub-Saharan Africa and the Arabian Peninsula. There are no approved antiviral therapies or vaccines available to treat or prevent severe disease associated with RVFV infection in humans. The adenosine analog, galidesivir (BCX4430), is a broad-spectrum antiviral drug candidate with in vitro antiviral potency (EC50 of less than 50 μM) in more than 20 different viruses across eight different virus families. Here we report on the activity of galidesivir in the hamster model of peracute RVFV infection. Intramuscular and intraperitoneal treatments effectively limited systemic RVFV (strain ZH501) infection as demonstrated by significantly improved survival outcomes and the absence of infectious virus in the spleen and the majority of the serum, brain, and liver samples collected from infected animals. Our findings support the further development of galidesivir as an antiviral therapy for use in treating severe RVFV infection, and possibly other related phleboviral diseases.
AuthorsJonna B Westover, Amanda Mathis, Ray Taylor, Luci Wandersee, Kevin W Bailey, Eric J Sefing, Brady T Hickerson, Kie-Hoon Jung, William P Sheridan, Brian B Gowen
JournalAntiviral research (Antiviral Res) Vol. 156 Pg. 38-45 (08 2018) ISSN: 1872-9096 [Electronic] Netherlands
PMID29864447 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2018 Elsevier B.V. All rights reserved.
Chemical References
  • Antiviral Agents
  • Purine Nucleosides
  • Pyrrolidines
  • Adenine
  • Adenosine
  • galidesivir
Topics
  • Adenine (analogs & derivatives)
  • Adenosine (analogs & derivatives)
  • Animals
  • Antiviral Agents (administration & dosage)
  • Disease Models, Animal
  • Injections, Intramuscular
  • Injections, Intraperitoneal
  • Liver (virology)
  • Mesocricetus
  • Purine Nucleosides (administration & dosage)
  • Pyrrolidines
  • Rift Valley Fever (drug therapy)
  • Rift Valley fever virus (drug effects)
  • Spleen (virology)
  • Survival Analysis
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: