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Marital Status and Survival of Patients with Hormone Receptor-Positive Male Breast Cancer: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Study.

Abstract
BACKGROUND Although marital status has been reported as a prognostic factor in different cancer types, its prognostic effect on hormone receptor (HR) positive male breast cancer (MBC) is unclear. The objective of the present analysis was to assess the effects of marital status on survival in patients with HR positive MBC. MATERIAL AND METHODS Patients diagnosed with HR positive MBC from 1990 to 2014 in the Surveillance, Epidemiology, and End Results (SEER) database were included. Kaplan-Meier survival analysis and Cox proportional hazard regression were used to identify the effects of marital status on cancer-specific survival (CSS) and overall survival (OS). RESULTS A total of 3612 cases were identified in this study. Married patients had better 5-year CSS and 5-year OS than unmarried men. In multivariate Cox regression models, unmarried patients also showed higher mortality risk for both CSS and OS, independent of age, race, grade, stage, PR status, HER2 status, and surgery. Subgroup survival analysis according to different ER/PR status showed that married patients had beneficial CSS results only in ER+/PR+ subtype, and CSS in the married and unmarried groups did not significantly differ by TNM stage. The results were further confirmed in the 1: 1 matched group. CONCLUSIONS Marital status was an important prognostic factor for survival in patients with HR positive MBC. Unmarried patients are at greater risk of death compared with married groups. The survival benefit for married patients remained even after adjustment, which indicates the importance of spousal support in MBC.
AuthorsLei Liu, Ya-Yun Chi, An-An Wang, Yonghui Luo
JournalMedical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 24 Pg. 3425-3441 (May 24 2018) ISSN: 1643-3750 [Electronic] United States
PMID29795054 (Publication Type: Journal Article)
Chemical References
  • Receptors, Steroid
Topics
  • Aged
  • Breast Neoplasms, Male (epidemiology, pathology)
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Marital Status
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Staging
  • Receptors, Steroid (metabolism)
  • SEER Program

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