Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study.

Abstract

BACKGROUND:

Most patients with ulcerative colitis (UC) rely predominantly on medication for disease control. Diet interventions can reduce pharmaceutical expenditures and prolong remission. We designed a prospective study to evaluate whether an immunoglobulin G (IgG)-guided exclusion diet would improve symptoms and quality of life (QoL) in patients with UC.

METHODS:

The 6-month diet intervention included 97 patients with UC, who were randomly divided into an intervention group (n = 49) and a control (n = 48) group. Individual diet plans were created for the intervention group according to IgG titers; the control group ate a healthy diet as normal. Observational indices included disease activity, extraintestinal manifestations, nutritional status, and QoL. Relationships between food-specific IgG antibodies and these indices were also analyzed.

RESULTS:

At baseline, there were no significant differences between the groups. Food-specific IgG antibodies were detected in 70.10% of participants. After intervention, the Mayo score was significantly lower in the intervention group than in the control group (2.41 ± 0.89 vs 3.52 ± 1.15, P < 0.05). The number of patients with extraintestinal manifestations decreased from 7 to 2 in the intervention group and from 6 to 5 in the control group. As for nutritive indices, the intervention group had higher mean body mass index and albumin than the control group (23.88 ± 3.31 vs 21.50 ± 6.24 kg/m2, respectively, P < 0.05; 48.05 ± 6.39 vs 45.72 ± 5.48 g/L, respectively, P < 0.05), whereas prealbumin and transferrin were not significantly different between the groups. QoL improved after food exclusion (P < 0.05).

CONCLUSIONS:

An IgG-guided exclusion diet ameliorated UC symptoms and improved QoL. Interactions between IgG-based food intolerance and UC warrant further study.

• Authors: Liu Jian, He Anqi, Liu Gang, Wang Litian, Xu Yanyan, Wang Mengdi, Liu Tong
• Journal: Inflammatory bowel diseases (Inflamm Bowel Dis) Vol. 24 Issue 9 Pg. 1918-1925 (08 16 2018) ISSN: 1536-4844 [Electronic] England
• PMID: 29788288 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2018 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Autoantibodies
• Immunoglobulin G

Topics

• Adult
• Aged
• Autoantibodies (blood, immunology)
• Colitis, Ulcerative (blood, diet therapy, immunology)
• Diet (methods)
• Female
• Food Analysis
• Food Intolerance (diet therapy, immunology)
• Humans
• Immunoglobulin G (immunology)
• Male
• Middle Aged
• Prospective Studies
• Quality of Life
• Treatment Outcome
• Young Adult