Psoriasis is one of the most frequently occurring chronic inflammatory
skin diseases. There are some specialized regions of the body that are considered difficult to treat.
Secukinumab is a human monoclonal
immunoglobulin G antibody that blocks the
interleukin 17A ligand and has been shown to be highly efficacious in treating moderate-to-severe
psoriasis. We studied two Greek patients, one with scalp
psoriasis and the other with palmoplantar
psoriasis, both resistant to treatment. Patients were treated with
secukinumab and efficacy and safety were recorded. The patient with severe, refractory palmoplantar
psoriasis achieved complete clearance at the end of the 4-week treatment period with
secukinumab. The patient with moderate to severe, chronic scalp
psoriasis was successfully treated with
secukinumab, obtaining complete clearance of symptoms and remission of disease after approximately 16 weeks. In both cases clinical response was maintained through week 52.
Secukinumab has been shown to be highly efficacious in the treatment of
psoriasis of specific anatomical sites with an acceptable safety profile.