[Long-term remission with mogamulizumab monotherapy in a patient with refractory adult T-cell leukemia-lymphoma].

Abstract

A 73-year-old female with malaise, anorexia, and hydrodipsia was referred to our department. Peripheral blood tests revealed leukocytosis with 51% blast cells exhibiting flower-shaped nuclei. Flow-cytometry to detect tumor cells in peripheral blood indicated CD3+, CD4+, CD8-, and CD25- expression, but those in the lymph nodes expressed CD25+. Southern blots revealed clonal HTLV-1 provirus in the tumor cells, consistent with adult T-cell leukemia-lymphoma. Cytotoxic chemotherapy was ineffective, but eight cycles of mogamulizumab induced complete remission (CR). A relapse lesion appeared on the right breast but disappeared spontaneously. The patient has currently maintained CR for over five years.

• Authors: Yosuke Nakaya, Minako Tsutsumi, Hoyuri Fuseya, Mirei Horiuchi, Takuro Yoshimura, Yoshiki Hayashi, Hiroshi Kanashima, Takafumi Nakao, Takahisa Yamane
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) 2018 Vol. 59 Issue 3 Pg. 326-328 ISSN: 0485-1439 [Print] Japan
• PMID: 29618693 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal, Humanized
• mogamulizumab

Topics

• Aged
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Female
• Human T-lymphotropic virus 1
• Humans
• Leukemia-Lymphoma, Adult T-Cell (drug therapy)
• Remission Induction