Long non-coding RNA-CTD-2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor.

Abstract

Breast cancer (BC) is an aggressive malignant disease in women worldwide with a high tendency to metastasize. However, important biomarkers for BC metastasis remain largely undefined. In the present study, we identified that long non-coding RNA-CTD-2108O9.1 is downregulated in BC tissues and cells and acts as a metastatic inhibitor of BC. Mechanistic investigation determined that lncRNA-CTD-2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor (LIFR), which is designated as a metastasis suppressor in BC. Our study characterizes a significant tumor suppressor active in BC metastasis repression through the known metastasis inhibitor LIFR.

• Authors: Mozhi Wang, Mengshen Wang, Zhenning Wang, Xueting Yu, Yongxi Song, Chong Wang, Yujie Xu, Fengheng Wei, Yi Zhao, Yingying Xu
• Journal: Cancer science (Cancer Sci) Vol. 109 Issue 6 Pg. 1764-1774 (Jun 2018) ISSN: 1349-7006 [Electronic] England
• PMID: 29603493 (Publication Type: Journal Article)
• Copyright: © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Chemical References

• RNA, Long Noncoding
• Receptors, OSM-LIF

Topics

• Animals
• Breast Neoplasms (genetics, pathology)
• Cell Line
• Cell Line, Tumor
• Cell Movement (genetics)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Lymphatic Metastasis
• MCF-7 Cells
• Mice, Inbred BALB C
• Mice, Nude
• Middle Aged
• RNA Interference
• RNA, Long Noncoding (genetics)
• Receptors, OSM-LIF (genetics)
• Transplantation, Heterologous