Abstract | Importance: Objectives: To determine the AQP4-IgG and MOG- IgG serostatus of patients within the ONTT and describe the clinical features of seropositive patients. Design, Setting, and Participants: In this follow-up study of the randomized clinical trial, ONTT, conducted between July 1, 1988, and June 30, 1991, analysis of serum for AQP4-IgG and MOG- IgG was performed from January 1 to April 30, 2017. A total of 177 patients from the ONTT with acute optic neuritis and serum available for analysis were enrolled from 13 academic referral centers. Interventions: Analysis of serum for AQP4-IgG and MOG- IgG was performed at Mayo Clinic Neuroimmunology Laboratory in 2017 with a flow cytometry, live cell, AQP4- and MOG-transfected cell-based assay. Main Outcomes and Measures: Aquaporin-4-IgG and MOG- IgG serostatus. Results: Of the 177 patients in the study (135 women and 42 men; mean [SD] age, 32.8 [6.9] years), 3 were positive for MOG- IgG (1.7%) and none were positive for AQP4-IgG. All 3 patients positive for MOG- IgG had disc edema at presentation. Two patients later had a single episode of recurrent optic neuritis. All 3 patients had complete recovery of visual acuity, and none were corticosteroid dependent, although peripheral visual field loss persisted in 1 patient. None of the 3 patients positive for MOG- IgG had demyelinating lesions on magnetic resonance imaging scans, and none had developed multiple sclerosis at the 15-year follow-up. Conclusions and Relevance:
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Authors | John J Chen, W Oliver Tobin, Masoud Majed, Jiraporn Jitprapaikulsan, James P Fryer, Jacqueline A Leavitt, Eoin P Flanagan, Andrew McKeon, Sean J Pittock |
Journal | JAMA ophthalmology
(JAMA Ophthalmol)
Vol. 136
Issue 4
Pg. 419-422
(04 01 2018)
ISSN: 2168-6173 [Electronic] United States |
PMID | 29470571
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Anti-Idiotypic
- Aquaporin 4
- Autoantibodies
- Biomarkers
- Glucocorticoids
- Immunoglobulin G
- Myelin-Oligodendrocyte Glycoprotein
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Topics |
- Adult
- Antibodies, Anti-Idiotypic
(blood, immunology)
- Aquaporin 4
(immunology)
- Autoantibodies
(blood, immunology)
- Biomarkers
(blood)
- Female
- Flow Cytometry
- Follow-Up Studies
- Glucocorticoids
(therapeutic use)
- Humans
- Immunoglobulin G
(immunology)
- Male
- Myelin-Oligodendrocyte Glycoprotein
(immunology)
- Optic Disk
(pathology)
- Optic Neuritis
(blood, drug therapy, immunology)
- Prevalence
- Prognosis
- Tomography, Optical Coherence
- Visual Acuity
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