Abstract | BACKGROUND AND OBJECTIVE:
Antipsychotic medication use has steadily increased in Canada, with an expansion in the profile of users and the diagnoses for which they are used. The use of antipsychotics is associated with a number of adverse effects for which routine monitoring is recommended. The objectives of this study were to determine the most common diagnoses associated with antipsychotic use in children in Alberta, Canada and the proportion who receive recommended laboratory tests for adverse effects. METHODS: Data on dispensed antipsychotics, diagnoses, prescribers, and laboratory testing were obtained from provincial data sources. To assess the frequency of metabolic and hormonal laboratory baseline and/or follow-up testing, the sample was divided into an antipsychotic-naïve cohort and an antipsychotic non-naïve cohort. RESULTS: CONCLUSIONS: The majority of antipsychotic use in children in Alberta is off-label and associated with disruptive behavior disorders, depression, and anxiety disorders. The vast majority of children prescribed antipsychotic medications do not undergo recommended laboratory tests.
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Authors | Wenxin Chen, Monica Cepoiu-Martin, Antonia Stang, Diane Duncan, Chris Symonds, Lara Cooke, Tamara Pringsheim |
Journal | Clinical drug investigation
(Clin Drug Investig)
Vol. 38
Issue 5
Pg. 449-455
(May 2018)
ISSN: 1179-1918 [Electronic] New Zealand |
PMID | 29453686
(Publication Type: Journal Article)
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Chemical References |
- Antipsychotic Agents
- Quetiapine Fumarate
- Risperidone
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Topics |
- Adolescent
- Alberta
(epidemiology)
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Attention Deficit Disorder with Hyperactivity
(drug therapy, epidemiology)
- Child
- Child Behavior Disorders
(drug therapy, epidemiology)
- Cohort Studies
- Drug Prescriptions
(standards)
- Female
- Follow-Up Studies
- Humans
- Male
- Neurodevelopmental Disorders
(drug therapy, epidemiology)
- Population Surveillance
(methods)
- Quetiapine Fumarate
(adverse effects, therapeutic use)
- Risperidone
(adverse effects, therapeutic use)
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