Health Benefits of Vanadium and Its Potential as an Anticancer Agent.

Abstract

Vanadium compounds have been known to have beneficial therapeutic properties since the turn of the century, but it was not until 1965 when it was discovered that those effects could be extended to treating cancer. Some vanadium compounds can combat common markers of cancer, which include metabolic processes that are important to initiating and developing the phenotypes of cancer. It is appropriate to consider vanadium as a treatment option due to the similarities in some of the metabolic pathways utilized by both diabetes and cancer and therefore is among the few drugs that are effective against more than one disease. The development of vanadium compounds as protein phosphatase inhibitors for the treatment of diabetes may be useful for potential applications as an anticancer agent. Furthermore, the ability of vanadium to redox cycle is also important for biological properties and is involved in the pathways of reactive oxygen species. Early agents including vanadocene and peroxovanadium compounds have been investigated in detail, and the results can be used to gain a better understanding of how some vanadium compounds are modifying the metabolic pathways potentially developing cancer. Considering the importance of coordination chemistry to biological responses, it is likely that proper consideration of compound formulation will improve the efficacy of the drug. Future development of vanadium-based drugs should include consideration of drug formulation at earlier stages of drug development.

• Authors: Debbie C Crans, Lining Yang, Allison Haase, Xiaogai Yang
• Journal: Metal ions in life sciences (Met Ions Life Sci) Vol. 18 (02 05 2018) ISSN: 1559-0836 [Print] Germany
• PMID: 29394028 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anticarcinogenic Agents
• Antineoplastic Agents
• Coordination Complexes
• Vanadium Compounds

Topics

• Animals
• Anticarcinogenic Agents (adverse effects, chemistry, metabolism, therapeutic use)
• Antineoplastic Agents (adverse effects, chemistry, metabolism, therapeutic use)
• Coordination Complexes
• Dietary Supplements (adverse effects)
• Drug Compounding
• Drug Discovery (methods)
• Humans
• Molecular Structure
• Neoplasms (drug therapy, metabolism, pathology, prevention & control)
• Structure-Activity Relationship
• Vanadium Compounds (adverse effects, chemistry, metabolism, therapeutic use)