Abstract | BACKGROUND: METHODS: RESULTS: Our results showed an inverse correlation between angiogenin expression and scar severity. Next, we examined the effects of angiogenin in scar fibroblasts. We found that angiogenin was persistently expressed in human scar fibroblasts and that angiogenin expression significantly increased with time in the culture medium of scar fibroblasts. Treatment of scar fibroblasts with recombinant angiogenin significantly decreased their proliferation and TGF-β1 secretion. Moreover, angiogenin inhibited TGF-β1-mediated Smad2 signaling pathway. CONCLUSION: Our data suggest a negative role of angiogenin in fibroblast proliferation via TGF-β1-mediated Smad2 signaling pathway.
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Authors | Shin-Chen Pan, Chou-Hwei Lee, Chung-Lin Chen, Wei-Yu Fang, Li-Wha Wu |
Journal | Annals of plastic surgery
(Ann Plast Surg)
Vol. 80
Issue 2S Suppl 1
Pg. S79-S83
(02 2018)
ISSN: 1536-3708 [Electronic] United States |
PMID | 29369907
(Publication Type: Journal Article)
|
Chemical References |
- Biomarkers
- SMAD2 protein, human
- Smad2 Protein
- TGFB1 protein, human
- Transforming Growth Factor beta1
- angiogenin
- Ribonuclease, Pancreatic
|
Topics |
- Biomarkers
(metabolism)
- Burns
(complications, pathology)
- Cell Proliferation
- Cells, Cultured
- Cicatrix, Hypertrophic
(etiology, metabolism, pathology)
- Cohort Studies
- Enzyme-Linked Immunosorbent Assay
(methods)
- Female
- Fibroblasts
(cytology, metabolism)
- Humans
- In Vitro Techniques
- Injury Severity Score
- Male
- Ribonuclease, Pancreatic
(metabolism)
- Sensitivity and Specificity
- Smad2 Protein
(metabolism)
- Transforming Growth Factor beta1
(metabolism)
- Wound Healing
(physiology)
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