Abstract | INTRODUCTION: METHODS: In a previous trial, patients with ileocecal Crohn's disease were randomized to either immediate ileocecal resection or medical treatment with Infliximab. In case of insufficient response to Infliximab, the latter underwent secondary ileocecal resection. We compared specimens from those patients undergoing immediate resection ( Infliximab naïve, n = 20) to those who failed Infliximab therapy (n = 20). RESULTS: DISCUSSION:
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Authors | Jessica R de Bruyn, Marte A Becker, Jessica Steenkamer, Manon E Wildenberg, Sybren L Meijer, Christianne J Buskens, Willem A Bemelman, Mark Löwenberg, Cyriel Y Ponsioen, Gijs R van den Brink, Geert R D'Haens |
Journal | PloS one
(PLoS One)
Vol. 13
Issue 1
Pg. e0190999
( 2018)
ISSN: 1932-6203 [Electronic] United States |
PMID | 29364909
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Extracellular Matrix Proteins
- Gastrointestinal Agents
- Infliximab
- Procollagen N-Endopeptidase
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Topics |
- Adult
- Crohn Disease
(complications, drug therapy, metabolism)
- Extracellular Matrix Proteins
(metabolism)
- Female
- Fibrosis
- Gastrointestinal Agents
(therapeutic use)
- Humans
- Infliximab
(therapeutic use)
- Intestinal Diseases
(complications, metabolism, pathology)
- Intestinal Mucosa
(enzymology)
- Male
- Middle Aged
- Procollagen N-Endopeptidase
(metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Young Adult
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