Abstract | OBJECTIVES: METHODS: 68Ga was obtained from 68Ge/68Ga generator. The complex was prepared at optimized conditions. Radiochemical purity of the complex was checked using both HPLC and ITLC methods. Biodistribution of the complex was studied in BALB/c mice bearing adenocarcinoma breast cancer. Also, PET/CT imaging was performed up to 120 min post injection. RESULTS: The complex was produced with radiochemical purity of greater than 98% and specific activity of about 40 GBq/mM at optimized conditions. Biodistribution of the complex was studied in BALB/c mice bearing adenocarcinoma breast cancer indicated fast blood clearance and significant uptake in the tumor. Significant tumor: blood and tumor:muscle uptake ratios were observed even at early times post-injection. PET/CT images were also confirmed the considerable accumulation of the tracer in the tumor. CONCLUSION: Generally, the results proved the possible application of the radiolabelled complex for the detection of the adenocarcinoma breast cancer and according to the pharmacokenitic data, the suitable time for imaging was determined as at least 30 min after injection.
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Authors | Samaneh Zolghadri, Mojdeh Naderi, Hassan Yousefnia, Behrouz Alirezapour, Davood Beiki |
Journal | Asia Oceania journal of nuclear medicine & biology
(Asia Ocean J Nucl Med Biol)
Vol. 6
Issue 1
Pg. 41-49
( 2018)
ISSN: 2322-5718 [Print] Iran |
PMID | 29333466
(Publication Type: Journal Article)
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