Novel Metal Polyphenol Framework for MR Imaging-Guided Photothermal Therapy.

Abstract

Phothermal therapy has received increasing attention in recent years as a potentially effective way to treat cancer. In pursuit of a more biocompatible photothermal agent, we utilize biosafe materials including ellagic acid (EA), polyvinylpyrrolidone (PVP), and iron element as building blocks, and we successfully fabricate a homogeneous nanosized Fe-EA framework for the first time by a facile method. As expected, the novel nanoagent exhibits no obvious cytotoxicity and good hemocompatibility in vitro and in vivo. The microenvironment responsiveness to both pH and hydrogen peroxide makes the NPs biodegradable in tumor tissues, and the framework should be easily cleared by the body. Photothermal potentials of the nanoparticles are demonstrated with relevant features of strong NIR light absorption, moderately effective photothermal conversion efficiency, and good photothermal stability. The in vivo photothermal therapy also achieved effective tumor ablation with no apparent toxicity. On the other hand, it also exhibits T2 MR imaging ability originated from ferric ions. Our work highlights the promise of the Fe-EA framework for imaging-guided photothermal therapy.

• Authors: Gaozheng Zhao, Huihui Wu, Ruilu Feng, Dongdong Wang, Pengping Xu, Peng Jiang, Kang Yang, Haibao Wang, Zhen Guo, Qianwang Chen
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 10 Issue 4 Pg. 3295-3304 (Jan 31 2018) ISSN: 1944-8252 [Electronic] United States
• PMID: 29300453 (Publication Type: Journal Article)

Chemical References

• Metals
• Polyphenols

Topics

• Hyperthermia, Induced
• Magnetic Resonance Imaging
• Metals
• Nanoparticles
• Phototherapy
• Polyphenols (chemistry)