CNS response to osimertinib in patients with T790M-positive advanced NSCLC: pooled data from two phase II trials.

Abstract

Background:

Central nervous system (CNS) metastases are common in patients with non-small-cell lung cancer (NSCLC). Osimertinib has shown systemic efficacy in patients with CNS metastases, and early clinical evidence shows efficacy in the CNS. To evaluate osimertinib activity further, we present a pre-specified subgroup analysis of CNS response using pooled data from two phase II studies: AURA extension (NCT01802632) and AURA2 (NCT02094261).

Patients and methods:

Patients with T790M-positive advanced NSCLC, who had progressed following prior epidermal growth factor receptor-tyrosine kinase inhibitor treatment, received osimertinib 80 mg od (n = 411). Patients with stable, asymptomatic CNS metastases were eligible for enrolment; prior CNS treatment was allowed. Patients with ≥1 measurable CNS lesion (per RECIST 1.1) on baseline brain scan by blinded independent central neuroradiology review (BICR) were included in the evaluable for CNS response set (cEFR). The primary outcome for this CNS analysis was CNS objective response rate (ORR) by BICR; secondary outcomes included CNS duration of response, disease control rate (DCR) and progression-free survival (PFS).

Results:

Of 128 patients with CNS metastases on baseline brain scans, 50 were included in the cEFR. Confirmed CNS ORR and DCR were 54% [27/50; 95% confidence interval (CI) 39-68] and 92% (46/50; 95% CI 81-98), respectively. CNS response was observed regardless of prior radiotherapy to the brain. Median CNS duration of response (22% maturity) was not reached (range, 1-15 months); at 9 months, 75% (95% CI 53-88) of patients were estimated to remain in response. Median follow-up for CNS PFS was 11 months; median CNS PFS was not reached (95% CI, 7, not calculable). The safety profile observed in the cEFR was consistent with the overall patient population.

Conclusions:

Osimertinib demonstrated clinically meaningful efficacy against CNS metastases, with a high DCR, encouraging ORR, and safety profile consistent with that reported previously.

ClinicalTrials.gov number:

NCT01802632; NCT02094261.

• Authors: G Goss, C-M Tsai, F A Shepherd, M-J Ahn, L Bazhenova, L Crinò, F de Marinis, E Felip, A Morabito, R Hodge, M Cantarini, M Johnson, T Mitsudomi, P A Jänne, J C-H Yang
• Journal: Annals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol) Vol. 29 Issue 3 Pg. 687-693 (03 01 2018) ISSN: 1569-8041 [Electronic] England
• PMID: 29293889 (Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acrylamides
• Aniline Compounds
• Antineoplastic Agents
• Piperazines
• osimertinib
• EGFR protein, human
• ErbB Receptors

Topics

• Acrylamides
• Adult
• Aged
• Aniline Compounds
• Antineoplastic Agents (therapeutic use)
• Brain Neoplasms (drug therapy, secondary)
• Carcinoma, Non-Small-Cell Lung (drug therapy, genetics, secondary)
• Central Nervous System Neoplasms (drug therapy, secondary)
• ErbB Receptors (genetics)
• Female
• Humans
• Lung Neoplasms (drug therapy, genetics, pathology)
• Male
• Middle Aged
• Piperazines (therapeutic use)
• Progression-Free Survival