Serum soluble interleukin-2 receptor as a biomarker in immunoglobulin G4-related disease.

Abstract

OBJECTIVES:

Serum soluble interleukin-2 (IL-2) receptor (sIL-2R) might reflect disease activity in immunoglobulin G4-related disease (IgG4-RD). We aimed to elucidate the clinical significance of blood markers, including sIL-2R, in patients with IgG4-RD.

METHODS:

We enrolled 59 patients with IgG4-RD and investigated the association between blood markers (white blood cells, C-reactive protein, sIL-2R, IgG, IgG4, IgE, total hemolytic complement), and clinical indices.

RESULTS:

At baseline, serum sIL-2R (Rs = 0.532, p < .001) and IgG4 (Rs = 0.545, p < .001) levels showed significant correlation to the number of organs involved. During follow-up period (median, 70 months; range, 7-195 months), 40 patients were treated with corticosteroids. Receiver operating characteristic (ROC) analysis showed that baseline sIL-2R levels most accurately predicted patients requiring glucocorticoid treatment (area under the ROC curve, 0.807). Among the 46 patients who improved, sIL-2R and IgG4 levels decreased in 42 and 41 patients, respectively. Among them, serum sIL-2R levels decreased to a normal range in 42 patients (91%), whereas IgG4 levels normalized in 19 (41%).

CONCLUSION:

The serum sIL-2R level is a potential biomarker for IgG4-RD that may reflect the number of involved organs and may predict patients requiring glucocorticoid treatment.

• Authors: Tomohiro Handa, Shoko Matsui, Hajime Yoshifuji, Yuzo Kodama, Hiroshi Yamamoto, Seijiro Minamoto, Yuko Waseda, Yasuharu Sato, Keishi Kubo, Tsuneyo Mimori, Tsutomu Chiba, Toyohiro Hirai, Michiaki Mishima
• Journal: Modern rheumatology (Mod Rheumatol) Vol. 28 Issue 5 Pg. 838-844 (Sep 2018) ISSN: 1439-7609 [Electronic] England
• PMID: 29251035 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Immunoglobulin G
• Receptors, Interleukin-2

Topics

• Adult
• Autoimmune Diseases (blood)
• Biomarkers (blood)
• Female
• Humans
• Immunoglobulin G (blood)
• Male
• Middle Aged
• Receptors, Interleukin-2 (blood)