Abstract | BACKGROUND: METHODS: Retrospective observational study of HHT patients treated with bevacizumab for a severe form of the disease in the 14 centers of the French HHT network. RESULTS: Forty-six patients (median age: 68 years) were treated between March 2009 and May 2015. Ten patients were treated for high output cardiac failure, 20 patients for severe hemorrhages and 16 for both indications. The standard protocol (6 infusions of 5mg/kg every 2 weeks) was initially used in 89% of the cases but diverse strategies were subsequently applied. A clinical improvement was noted by the referent physician for 74% of the patients with a median effect's duration of 6 months. Wound healing complications led to 2 amputations. Arthralgia/ arthritis and arterial hypertension occurred in 5 patients each. One third of the patients were dead at the time of the final update, coherently with age and the poor prognosis of these highly symptomatic patients. CONCLUSION: Intravenous bevacizumab seems to provide a clinical benefice in severe HHT patients. Precautions concerning wound healing and vascular pathologies must be respected. Prospective double blinded versus placebo trials are needed.
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Authors | Alexandre Guilhem, Anne-Emmanuelle Fargeton, Anne-Claire Simon, Pierre Duffau, Jean-Robert Harle, Christian Lavigne, Marie-France Carette, Olivier Bletry, Pierre Kaminsky, Vanessa Leguy, Nathalie Lerolle, Dominique Roux, Marc Lambert, Thierry Chinet, Delphine Bonnet, Sophie Dupuis-Girod, Sophie Rivière |
Journal | PloS one
(PLoS One)
Vol. 12
Issue 11
Pg. e0188943
( 2017)
ISSN: 1932-6203 [Electronic] United States |
PMID | 29190827
(Publication Type: Journal Article, Observational Study)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Bevacizumab
(administration & dosage, therapeutic use)
- Female
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Retrospective Studies
- Telangiectasia, Hereditary Hemorrhagic
(drug therapy)
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