Abstract | BACKGROUND: METHODS: This was a randomized, double-blind, triple-dummy, crossover study in healthy male and female recreational central nervous system (CNS) depressant users aged 18-55years, who could distinguish between the subjective effects of alprazolam 2mg and placebo. All participants received single doses of brivaracetam (50 [therapeutic dose], 200, 1000mg [supratherapeutic doses]), alprazolam (1.5, 3mg), placebo, and levetiracetam (4000mg) in random order each separated by 7-10days. Subjective Visual Analogue Scales (VAS) and Addiction Research Center Inventory (ARCI) scales were completed at intervals up to 24h postdose. Primary endpoints were Drug Liking (at this moment) VAS, Overall Drug Liking VAS, Feeling High VAS, and ARCI Pentobarbital Chlorpromazine Alcohol Group (PCAG, sedation) maximum effect (Emax). Maximum effect values on each scale were analyzed using a mixed-effect model (per protocol population, N=44). RESULTS: CONCLUSION: This study in healthy recreational CNS depressant users showed that single doses of brivaracetam 50mg (therapeutic single dose) had lower sedative, positive, and negative drug effects than alprazolam, while brivaracetam 200 and 1000mg (supratherapeutic single doses) were more similar to alprazolam. The subjective profile of brivaracetam appeared to be similar to that of levetiracetam, but further evaluation using a range of levetiracetam doses would be needed to confirm similar abuse potential.
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Authors | Kerri A Schoedel, Armel Stockis, Edward M Sellers |
Journal | Epilepsy & behavior : E&B
(Epilepsy Behav)
Vol. 78
Pg. 194-201
(01 2018)
ISSN: 1525-5069 [Electronic] United States |
PMID | 29153631
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Chemical References |
- Anticonvulsants
- Central Nervous System Depressants
- Hypnotics and Sedatives
- Illicit Drugs
- Pyrrolidinones
- Levetiracetam
- brivaracetam
- Alprazolam
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Topics |
- Adolescent
- Adult
- Alprazolam
(administration & dosage, adverse effects, pharmacology)
- Anticonvulsants
(administration & dosage, adverse effects, pharmacology)
- Central Nervous System Depressants
(administration & dosage, adverse effects, pharmacology)
- Cross-Over Studies
- Double-Blind Method
- Drug-Related Side Effects and Adverse Reactions
- Euphoria
- Female
- Humans
- Hypnotics and Sedatives
(administration & dosage, adverse effects, pharmacology)
- Illicit Drugs
(adverse effects)
- Levetiracetam
(administration & dosage, adverse effects, pharmacology)
- Male
- Middle Aged
- Pyrrolidinones
(administration & dosage, adverse effects, pharmacology)
- Young Adult
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