Abstract |
Ursolic acid (UA), a natural triterpene acid, is a promising anti- cancer drug due to its inhibitory effect on tumor growth and metastasis. However, clinical translation of UA is limited by its poor water solubility and low bioavailability. To overcome these problems, herein an amphiphilic self-assembly nanodrug composed of UA, lactobionic acid (LA) and low- polyamidoamine (low-PAMAM) dendrimers is developed. This near-spherical nanodrug with a uniform size (~180 nm) demonstrated to have an enhanced cytotoxicity against liver cancer SMMC7721 cells, and could attenuate the migration and adhesion of SMMC7721 cells at non-toxic concentrations by suppressing metastasis-related protein MMP-9 expression. Furthermore, in vivo study indicates that the nanodrug exhibited prolonged circulation time in blood as well as increased AUC, MRT and Cmax, and could effectively inhibit the tumor growth in H22 mice model. Overall, the UA-based nanodrug delivery system reported in the present work represents a novel strategy for targeted tumor therapy.
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Authors | Zhichun Shen, Bowen Li, Yajun Liu, Guirong Zheng, Yan Guo, Ruirui Zhao, Kai Jiang, Lulu Fan, Jingwei Shao |
Journal | Nanomedicine : nanotechnology, biology, and medicine
(Nanomedicine)
Vol. 14
Issue 2
Pg. 227-236
(02 2018)
ISSN: 1549-9642 [Electronic] United States |
PMID | 29128661
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Dendrimers
- Disaccharides
- Drug Carriers
- PAMAM Starburst
- Triterpenes
- lactobionic acid
- Matrix Metalloproteinase 9
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, chemistry)
- Carcinoma, Hepatocellular
(drug therapy)
- Cell Adhesion
(drug effects)
- Cell Proliferation
(drug effects)
- Dendrimers
(chemistry)
- Disaccharides
(chemistry)
- Drug Carriers
- Drug Delivery Systems
- Liver Neoplasms, Experimental
(drug therapy, pathology)
- Matrix Metalloproteinase 9
(metabolism)
- Mice
- Nanoparticles
(administration & dosage, chemistry)
- Neoplasm Metastasis
- Rats
- Rats, Sprague-Dawley
- Triterpenes
(chemistry)
- Tumor Cells, Cultured
- Ursolic Acid
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