Abstract | BACKGROUND: METHODS: We retrospectively reviewed the medical records of all children diagnosed with KFD during the period January 1992 to September 2016 at a tertiary medical center in Taiwan. RESULTS: 40 patients were histopathologically confirmed as KFD, and the mean age of the patients was 13.9 ± 3.1 years. The male to female ratio was 1:1. The lymph node involvements were often cervical (95%) with features of unilateral predisposition (75%), polyadenopathy (84.4%) and tenderness (56.3%). Fever, cough, rhinorrhea, and tonsillitis were other common presentations. Laboratory findings included leukopenia (56.5%), monocytosis (63.6%), with positive results of EB-VCA IgG (88.9%), EB-VCA IgM (22.2%), EBEA IgG (22.2%) and EBNA IgG (88.9%). The univariate analyses of prolonged fever with lymphopenia, monocytosis, thrombocytopenia and necrotizing type in histopathology were disclosed as statistically significant (P < 0.05). Corticosteroids and hydroxychloroquine were administered in 15.6% of patients respectively, along with symptomatic treatments for the rest. Recurrence occurred in 13.0% of patients without corticosteroids or hydroxychloroquine treatment. There were neither recurrences nor relevant major adverse effects in all the five KFD cases treated with hydroxychloroquine. CONCLUSION:
|
Authors | Yung-Chih Lin, Hsiu-Hui Huang, Bao-Ren Nong, Po-Yen Liu, Ying-Yao Chen, Yung-Feng Huang, Yee-Hsuan Chiou, Herng-Sheng Lee |
Journal | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
(J Microbiol Immunol Infect)
Vol. 52
Issue 3
Pg. 395-401
(Jun 2019)
ISSN: 1995-9133 [Electronic] England |
PMID | 29050748
(Publication Type: Journal Article)
|
Copyright | Copyright © 2017. Published by Elsevier B.V. |
Chemical References |
- Adrenal Cortex Hormones
- Hydroxychloroquine
|
Topics |
- Adolescent
- Adrenal Cortex Hormones
(therapeutic use)
- Biopsy
- Child
- Diagnosis, Differential
- Female
- Histiocytic Necrotizing Lymphadenitis
(diagnosis, drug therapy, pathology)
- Humans
- Hydroxychloroquine
(therapeutic use)
- Lymph Nodes
(pathology)
- Male
- Recurrence
- Retrospective Studies
- Taiwan
- Treatment Outcome
|