Abstract | OBJECTIVE: MATERIALS AND METHODS: RESULTS: A low dose proliferative effect of phthalates in vitro was observed. With the hypothesis of the inhibition of aerobic glycolysis activity in cancer treatment, α- lipoic acid was applied to cells; where as a contrary to previous studies, no change in the cell proliferation was observed. In combination with ALA, at IC50 and lower doses, an increase of the cytotoxic effect was found for DIBP, DBP and BBP; while for DMP, DEP and DEHP, a decrease was observed for DU145 cells. In PC3 cells, a decrease was observed for DMP, DEP and DBPs; while no significant difference were observed for DEHP, DIBP and BBP. CONCLUSSION: The present study demonstrates preliminary information regarding the low dose proliferative effects of phthalates in prostate cancer in vitro (Tab. 2, Fig. 2, Ref. 65).
|
Authors | G Kismali, B Yurdakok-Dikmen, O Kuzukiran, P Arslan, A Filazi |
Journal | Bratislavske lekarske listy
(Bratisl Lek Listy)
Vol. 118
Issue 8
Pg. 460-466
( 2017)
ISSN: 0006-9248 [Print] Slovakia |
PMID | 29050483
(Publication Type: Journal Article)
|
Chemical References |
- Phthalic Acids
- dimethyl phthalate
- Dibutyl Phthalate
- Thioctic Acid
- Diethylhexyl Phthalate
- diisobutyl phthalate
- diethyl phthalate
- butylbenzyl phthalate
|
Topics |
- Adenocarcinoma
- Cell Death
(drug effects)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Dibutyl Phthalate
(analogs & derivatives, pharmacology)
- Diethylhexyl Phthalate
(pharmacology)
- Humans
- Male
- Phthalic Acids
(pharmacology)
- Prostatic Neoplasms
- Thioctic Acid
(pharmacology)
|