The first report of human primary thoracic spine mast cell sarcoma: a case report.

Abstract

In this report, we present a 53-year-old woman with primary mast cell sarcoma of the thoracic spine vertebrae. Mast cell sarcoma is an aggressive and rare cancer. To date, no cases of primary mast cell sarcoma have been reported in the spinal vertebrae. The patient initially presented with a 1-month history of pelvic and abdominal pain. Inconclusive gynecological evaluation resulted in a CT of the abdomen and pelvis, demonstrating a destructive lesion centered at the 11th thoracic vertebral body. The patient underwent a two-stage spine operation for T11 corpectomy and T7-L3 posterior spinal fusion. Histopathological, immunohistochemical, and flow cytometry studies of the resection specimens showed the tumor to be mostly composed of CD117-positive and mast cell tryptase-positive cells with features consistent with mast cell sarcoma. This is the first reported case of primary vertebral mast cell sarcoma, which may mimic other destructive lesions of the spine including osteomyelitis, vertebral tuberculosis, or plasmacytoma.
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• Authors: Ali C Ravanpay, Jonathan R Fromm, Kerstin L Edlefsen, Paul Martin, Randal Chesnut
• Journal: Clinical neuropathology (Clin Neuropathol) 2018 Jan/Feb Vol. 37 Issue 1 Pg. 28-35 ISSN: 0722-5091 [Print] Germany
• PMID: 28992848 (Publication Type: Case Reports, Journal Article)

Topics

• Female
• Humans
• Mast-Cell Sarcoma (diagnosis, pathology, surgery)
• Middle Aged
• Neurosurgical Procedures (methods)
• Spinal Neoplasms (pathology, surgery)
• Thoracic Vertebrae (pathology, surgery)
• Treatment Outcome