Emerging roles of syndecan 2 in epithelial and mesenchymal cancer progression.

Abstract

Syndecan 2 (SDC2) belongs to a four-member family of evolutionary conserved small type I transmembrane proteoglycans consisting of a protein core to which glycosaminoglycan chains are covalently attached. SDC2 is a cell surface heparan sulfate proteoglycan, which is increasingly drawing attention for its distinct characteristics and its participation in numerous cell functions, including those related to carcinogenesis. Increasing evidence suggests that the role of SDC2 in cancer pathogenesis is dependent on cancer tissue origin rendering its use as a biomarker/therapeutic target feasible. This mini review discusses the mechanisms, through which SDC2, in a distinct manner, modulates complex signalling networks to affect cancer progression. © 2017 IUBMB Life, 69(11):824-833, 2017.

• Authors: Maria Mytilinaiou, Dragana Nikitovic, Aikaterini Berdiaki, Antonis Kostouras, Antonis Papoutsidakis, Aristidis M Tsatsakis, George N Tzanakakis
• Journal: IUBMB life (IUBMB Life) Vol. 69 Issue 11 Pg. 824-833 (11 2017) ISSN: 1521-6551 [Electronic] England
• PMID: 28940845 (Publication Type: Journal Article, Review)
• Copyright: © 2017 International Union of Biochemistry and Molecular Biology.

Chemical References

• Intercellular Signaling Peptides and Proteins
• SDC2 protein, human
• Syndecan-2

Topics

• Actin Cytoskeleton (metabolism, pathology)
• Breast Neoplasms (genetics, metabolism, pathology)
• Cell Line, Tumor
• Cell Membrane (metabolism, pathology)
• Colonic Neoplasms (genetics, metabolism, pathology)
• Disease Progression
• Female
• Fibrosarcoma (genetics, metabolism, pathology)
• Gene Expression Regulation, Neoplastic
• Humans
• Intercellular Signaling Peptides and Proteins (genetics, metabolism)
• Organ Specificity
• Osteosarcoma (genetics, metabolism, pathology)
• Pancreatic Neoplasms (genetics, metabolism, pathology)
• Protein Domains
• Signal Transduction
• Syndecan-2 (genetics, metabolism)