Abstract | AIMS/HYPOTHESIS: METHODS:
Insulin response was assessed by hyperinsulinaemic-euglycaemic clamp analysis and energy balance was analysed by indirect calorimetry. Mice were overnight-fasted and refed for 7 h to assess fatty acid synthase activity in the liver and the hypothalamus in response to insulin release during refeeding. RESULTS: CONCLUSIONS/INTERPRETATION: Despite the potential confounding effects of deleting Cc1 from extrahepatic tissues, liver-based rescuing of CEACAM1 resulted in full normalisation of the metabolic phenotype, underscoring the key role that CEACAM1-dependent hepatic insulin clearance pathways play in regulating systemic insulin sensitivity, lipid homeostasis and energy balance.
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Authors | Lucia Russo, Harrison T Muturi, Hilda E Ghadieh, Simona S Ghanem, Thomas A Bowman, Hye Lim Noh, Sezin Dagdeviren, Godwin Y Dogbey, Jason K Kim, Garrett Heinrich, Sonia M Najjar |
Journal | Diabetologia
(Diabetologia)
Vol. 60
Issue 12
Pg. 2463-2474
(12 2017)
ISSN: 1432-0428 [Electronic] Germany |
PMID | 28913658
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
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Chemical References |
- Carcinoembryonic Antigen
- Ceacam1 protein, mouse
- Fatty Acid Synthases
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Topics |
- Animals
- Carcinoembryonic Antigen
(genetics, metabolism)
- Energy Metabolism
(genetics, physiology)
- Fatty Acid Synthases
(genetics, metabolism)
- Fatty Liver
(genetics, metabolism)
- Hyperinsulinism
(genetics, metabolism)
- Insulin Resistance
(genetics, physiology)
- Lipolysis
(genetics, physiology)
- Liver
(metabolism)
- Male
- Mice
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