Soyabean Oil Supplementation Effects on Perivascular Inflammation in Lungs Induced by Bisphenol A: A Histological Study.

Abstract

OBJECTIVE:

To determine the effect of soyabean oil supplementation on perivascular inflammation in lungs of adult mice induced by Bisphenol A(BPA).

STUDY DESIGN:

An experimental study.

PLACE AND DURATION OF STUDY:

Department of Anatomy, Army Medical College, Rawalpindi, in collaboration with the Animal House, National Institute of Health, Islamabad, from June to November 2016.

METHODOLOGY:

Thirty male and female BALB/c mice were divided into three groups, of 10 animals each. Group Aanimals served as control. Group B animals were given BPAat a dose of 50 mg/Kg body weight/day. Group C animals were given BPAand soyabean oil at doses of 50 mg/Kg body weight/day and 500 mg/day, respectively. All treatments were given once daily for a period of eight weeks. Animals were dissected 24 hours after receiving the last dose. Lung tissue specimen processing and H&E staining was carried out for routine histological study. Perivascular inflammation was morphometrically graded and statistically analysed using Chi-square test with p<0.05.

RESULTS:

Grade 2 inflammation was recorded in two (20%) animals and grade 3 perivascular inflammation in 80% specimens in Group B; whereas 20% specimens of Group C had grade 2 inflammation and eight (80%) showed grade 1 inflammation. None of the control animals showed any inflammation. All groups were significantly different at p<0.001.

CONCLUSION:

BPAproduced perivascular inflammation and con-commitant administration of soyabean oil diet protected against it in rodent.

• Authors: Sadia Shaukat, Shabnam Hamid, Faiza Umbreen
• Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP (J Coll Physicians Surg Pak) Vol. 27 Issue 8 Pg. 463-465 (Aug 2017) ISSN: 1681-7168 [Electronic] Pakistan
• PMID: 28903835 (Publication Type: Journal Article)

Chemical References

• Benzhydryl Compounds
• Phenols
• Soybean Oil
• bisphenol A

Topics

• Animals
• Benzhydryl Compounds (adverse effects)
• Bronchial Hyperreactivity (chemically induced, diet therapy)
• Female
• Inflammation (chemically induced, diet therapy)
• Lung (drug effects)
• Male
• Mice
• Mice, Inbred BALB C
• Phenols (adverse effects)
• Soybean Oil (therapeutic use)