Review of triazine antiprotozoal drugs used in veterinary medicine.

Abstract

Triazines are relatively new antiprotozoal drugs that have successfully controlled coccidiosis and equine protozoal myeloencephalitis. These drugs have favorably treated other protozoal diseases such as neosporosis and toxoplasmosis. In this article, we discuss the pharmacological characteristics of five triazines, toltrazuril, ponazuril, clazuril, diclazuril, and nitromezuril which are used in veterinary medicine to control protozoal diseases which include coccidiosis, equine protozoal myeloencephalitis, neosporosis, and toxoplasmosis.

• Authors: M L Stock, S T Elazab, W H Hsu
• Journal: Journal of veterinary pharmacology and therapeutics (J Vet Pharmacol Ther) Vol. 41 Issue 2 Pg. 184-194 (Apr 2018) ISSN: 1365-2885 [Electronic] England
• PMID: 28833212 (Publication Type: Journal Article, Review)
• Copyright: © 2017 John Wiley & Sons Ltd.

Chemical References

• 2-(3-methyl-4-(4-nitrophenoxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione
• Acetonitriles
• Antiprotozoal Agents
• Nitriles
• Triazines
• ponazuril
• diclazuril
• clazuril
• toltrazuril

Topics

• Acetonitriles (therapeutic use)
• Animals
• Antiprotozoal Agents (therapeutic use)
• Coccidiosis (drug therapy, veterinary)
• Encephalomyelitis, Equine (drug therapy, parasitology, veterinary)
• Horses
• Nitriles (therapeutic use)
• Protozoan Infections, Animal (drug therapy)
• Toxoplasmosis, Animal (drug therapy)
• Triazines (therapeutic use)