D-
Allulose-containing rare
sugar sweeteners have been categorized into two types, rare
sugar syrup (RSS), consisting of 4 rare
monosaccharides, and modified
glucose syrup (MGS), rich in D-
allulose, which was previously referred to
D-psicose. The anti-
obesity effect of RSS and D-
allulose has been already clarified, but that of rare
monosaccharides other than D-
allulose in RSS has not yet been well understood. Here, we investigated and compared the anti-
obesity effect of RSS and MGS in rats. Male Wistar rats were divided into 4 dietary groups: a high-
sucrose control diet group (S), a
high-fructose corn syrup diet group (HFCS), an RSS diet group (RSS), and an MGS diet group (MGS). RSS significantly suppressed abdominal adipose tissue weight and total body fat accumulation in comparison to
sucrose. On the other hand, MGS reduced
body weight gain, but not abdominal fat accumulation, relative to
sucrose. The weight of the liver and kidneys was significantly higher in the RSS and MGS groups than in the S and HFCS groups, but serum biochemical parameters and hepatic
lipids contents were not significantly different among the groups. The present study shows that two types of D-
allulose-containing rare
sugar sweeteners can suppress body fat accumulation or
weight gain in a different manner and that RSS could be used as more effective
sweeteners in place of
sucrose and HFCS to maintain healthy
body weight.