Efficacy of low carbohydrate diet for type 2 diabetes mellitus management: A systematic review and meta-analysis of randomized controlled trials.

Abstract

AIMS:

The objective of this systematic review and meta-analysis is to assess the efficacy of Low Carbohydrate Diet (LCD) compared with a normal or high carbohydrate diet in patients with type 2 diabetes.

METHODS:

We searched MEDLINE, EMBASE, and Cochrane Library database for randomized controlled trials. Researches which reported the change in weight loss, blood glucose, and blood lipid levels were included.

RESULTS:

A total of 9 studies with 734 patients with diabetes were included. Pooled results suggested that LCD had a significantly effect on HbA1c level (WMD: -0.44; 95% CI: -0.61, -0.26; P=0.00). For cardiovascular risk factors, the LCD intervention significantly reduced triglycerides concentration (WMD: -0.33; 95% CI: -0.45, -0.21; P=0.00) and increased HDL cholesterol concentration (WMD: 0.07; 95% CI: 0.03, 0.11; P=0.00). But the LCD was not associated with decreased level of total cholesterol and LDL cholesterol. Subgroup analyses indicated that short term intervention of LCD was effective for weight loss (WMD: -1.18; 95% CI: -2.32, -0.04; P=0.04).

CONCLUSIONS:

The results suggested a beneficial effect of LCD intervention on glucose control in patients with type 2 diabetes. The LCD intervention also had a positive effect on triglycerides and HDL cholesterol concentrations, but without significant effect on long term weight loss.

• Authors: Yan Meng, Hao Bai, Shijun Wang, Zhaoping Li, Qian Wang, Liyong Chen
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 131 Pg. 124-131 (Sep 2017) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 28750216 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
• Copyright: Copyright © 2017. Published by Elsevier B.V.

Topics

• Diabetes Mellitus, Type 2 (therapy)
• Diet, Carbohydrate-Restricted (methods)
• Humans
• Randomized Controlled Trials as Topic
• Risk Factors
• Weight Loss (physiology)