Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells.

Abstract

CD147 is a glycosylated transmembrane protein highly expressed on the surface of various tumor cells which plays vital roles in tumor invasion, progression and metastasis. We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizing a PAB-derived photoaffinity probe which could serve as a novel type of anticancer reagent.

• Authors: Yiqing Zhou, Zhengao Di, Xiaoming Li, Yuanhong Shan, Weichao Li, Haibing Zhang, Youli Xiao
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 53 Issue 62 Pg. 8671-8674 (Aug 11 2017) ISSN: 1364-548X [Electronic] England
• PMID: 28721406 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• BSG protein, human
• CCN1 protein, human
• Cysteine-Rich Protein 61
• Diterpenes
• Photoaffinity Labels
• Tubulin
• Basigin
• pseudolaric acid B
• MMP7 protein, human
• Matrix Metalloproteinase 7
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9

Topics

• Amino Acid Sequence
• Animals
• Antineoplastic Agents (pharmacology)
• Basigin (genetics, metabolism)
• Cysteine-Rich Protein 61 (genetics, metabolism)
• Diterpenes (pharmacology)
• Gene Knockdown Techniques
• HeLa Cells
• Humans
• Matrix Metalloproteinase 2 (metabolism)
• Matrix Metalloproteinase 7 (metabolism)
• Matrix Metalloproteinase 9 (metabolism)
• Photoaffinity Labels (pharmacology)
• Proteomics
• Swine
• Tubulin (metabolism)