Anti-biofilm properties of a mupirocin spray formulation against Escherichia coli wound infections.

Abstract

Mupirocin ointment is a widely used topical drug for the treatment of bacterial skin infections. However, ointments have some limitations which motivated the development of a film forming spray of mupirocin. Mupirocin spray (2%) was formulated with Eudragit E100 as a film forming agent and tested for its antibacterial and anti-biofilm activities against Escherichia coli, a skin pathogen causing wound and surgical site infections. Treatment with mupirocin spray resulted in significant antibacterial and anti-biofilm activities (inhibition and disruption) with single spray and sub-actual dose concentrations at par with the commercial ointment concentration. The spray formulation was found to be non-toxic to fibroblast cells and greatly resisted removal from the site of application upon washing, in contrast to the ointment which was significantly removed after a single wash. This is the first study to develop and evaluate a spray formulation for mupirocin that forms a stable thin film for sustained release of the drug.

• Authors: Dhamodharan Bakkiyaraj, Rutthapol Sritharadol, Alwar Ramanujam Padmavathi, Titpawan Nakpheng, Teerapol Srichana
• Journal: Biofouling (Biofouling) Vol. 33 Issue 7 Pg. 591-600 (08 2017) ISSN: 1029-2454 [Electronic] England
• PMID: 28686044 (Publication Type: Journal Article)

Chemical References

• Acrylates
• Aerosols
• Anti-Bacterial Agents
• Eudragit E100
• Ointments
• Polymers
• Mupirocin

Topics

• Acrylates (chemistry)
• Administration, Cutaneous
• Aerosols
• Anti-Bacterial Agents (administration & dosage, pharmacology, toxicity)
• Biofilms (drug effects)
• Cell Line
• Cell Survival (drug effects)
• Drug Compounding
• Escherichia coli (drug effects, isolation & purification)
• Humans
• Mupirocin (administration & dosage, pharmacology, toxicity)
• Ointments
• Polymers (chemistry)
• Skin Diseases, Bacterial (drug therapy)
• Staphylococcal Infections (drug therapy)
• Wound Infection (drug therapy)