Polyketide derivatives from a marine-sponge-associated fungus Pestalotiopsis heterocornis.

Abstract

Twelve previously undescribed polyketide derivatives, heterocornols A-L, and seven known analogues were isolated from a culture of the fungus Pestalotiopsis heterocornis associated with sponge. Their structures were elucidated by a comprehensive spectroscopic data analysis and CD Cotton effects. These compounds were evaluated for cytotoxic and antibacterial activities in vitro. Among them, heterocornols A-C, F-H, methyl-(2-formyl-3-hydroxyphenyl)propanoate, agropyrenol, and vaccinol G exhibited cytotoxicities against four human cancer cell lines with IC50 values 15-100 μM, and they also showed antibacterial activities against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis with MIC values ranging from 25 to 100 μg/mL. Moreover, compounds heterocornol C, heterocornol G, agropyrenol, and vaccinol G showed weak antifungal activities against Candida parapsilosis and Cryptococcus neoformans with MIC values 100 μg/mL.

• Authors: Hui Lei, Xiuping Lin, Li Han, Jian Ma, Kailin Dong, Xingbo Wang, Jialiang Zhong, Yu Mu, Yonghong Liu, Xueshi Huang
• Journal: Phytochemistry (Phytochemistry) Vol. 142 Pg. 51-59 (Oct 2017) ISSN: 1873-3700 [Electronic] England
• PMID: 28675830 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Antifungal Agents
• Naphthalenes
• Polyketides
• agropyrenol
• heterocornol C
• heterocornol G
• vaccinol G
• Doxorubicin

Topics

• Animals
• Anti-Bacterial Agents (chemistry, isolation & purification, pharmacology)
• Antifungal Agents (chemistry, isolation & purification, pharmacology)
• Bacillus subtilis (drug effects)
• Candida albicans (drug effects)
• Cryptococcus neoformans (drug effects)
• Crystallography, X-Ray
• Doxorubicin (pharmacology)
• Drug Screening Assays, Antitumor
• Humans
• Male
• Marine Biology
• Microbial Sensitivity Tests
• Molecular Conformation
• Molecular Structure
• Naphthalenes
• Nuclear Magnetic Resonance, Biomolecular
• Polyketides (chemistry, isolation & purification, pharmacology)
• Porifera (microbiology)
• Staphylococcus aureus (drug effects)
• Xylariales (chemistry)