Abstract | INTRODUCTION: The role of complement, especially through the C5a fragment, is well-known for the initiation of inflammation. Its involvement in regeneration has been shown more recently by the recruitment of mesenchymal stem cells. C5a can be produced locally by the pulp fibroblasts in response to injury or infection. This work aims to investigate the effect of different pulp capping biomaterials on complement activation and its possible influence on inflammatory and pulp stem cell recruitment. METHODS: RESULTS: CONCLUSIONS: After pulp injury, the pulp capping material affects complement activation and the balance between inflammation and regeneration through a differential recruitment of DPSCs or inflammatory cells.
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Authors | Thomas Giraud, Pierre Rufas, Fanny Chmilewsky, Charlotte Rombouts, Jacques Dejou, Charlotte Jeanneau, Imad About |
Journal | Journal of endodontics
(J Endod)
Vol. 43
Issue 7
Pg. 1104-1110
(Jul 2017)
ISSN: 1878-3554 [Electronic] United States |
PMID | 28527850
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Aluminum Compounds
- Calcium Compounds
- Dentin-Bonding Agents
- Drug Combinations
- Oxides
- Pulp Capping and Pulpectomy Agents
- Silicates
- Xeno III
- mineral trioxide aggregate
- tricalcium silicate
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Topics |
- Aluminum Compounds
(pharmacology)
- Calcium Compounds
(pharmacology)
- Cells, Cultured
- Complement Activation
(drug effects)
- Dental Pulp
(drug effects)
- Dental Pulp Capping
(methods)
- Dentin-Bonding Agents
(pharmacology)
- Drug Combinations
- Enzyme-Linked Immunosorbent Assay
- Fluorescent Antibody Technique
- Humans
- In Vitro Techniques
- Oxides
(pharmacology)
- Pulp Capping and Pulpectomy Agents
(pharmacology)
- Pulpitis
(metabolism)
- Silicates
(pharmacology)
- Stem Cells
(drug effects, metabolism)
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