Abstract | BACKGROUND: OBJECTIVE: To explore the natural course of YJ venom allergy and the diagnostic accuracy and therapeutic consequence of YJ venom sIgE in patients with ISM. METHODS: All patients with ISM seen from 1981 to 2015 (n = 243) were evaluated on the number of YJ stings, reaction severity, and sensitivity and specificity of YJ venom sIgE. YJ venom allergic patients without mastocytosis served as control (n = 313). RESULTS: A total of 153 patients with ISM were stung during adult life. The first systemic reaction was more often severe in patients with ISM than in patients without mastocytosis (69.9% vs 22.0%) and reactions recurred in 40 of 41 re-stung patients with ISM. ISM reactors showed lower YJ venom sIgE levels than nonmastocytosis reactors (0.61 vs 4.83 kUA/L; P < .001) and asymptomatic sensitization was exceedingly rare. In ISM the current clinical threshold of 0.35 kUA/L yields a sensitivity and specificity of 77.6% and 87.5%, respectively. The optimal diagnostic accuracy is achieved at 0.17 kUA/L (sensitivity, 83.6%; specificity, 85.0%). CONCLUSIONS: The high rate of severe reactions and the fatal case underscore the importance of adequate diagnostic sensitivity of sIgE in patients with ISM. The sensitivity of sIgE can be ameliorated by lowering the threshold to 0.17 kUA/L, retaining good specificity. We recommend sIgE screening in all patients with ISM and discussing immunotherapy when YJ venom sIgE exceeds 0.17 kUA/L.
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Authors | Byrthe J P R Vos, Bjorn van Anrooij, Jasper J van Doormaal, Anthony E J Dubois, Joanne N G Oude Elberink |
Journal | The journal of allergy and clinical immunology. In practice
(J Allergy Clin Immunol Pract)
2017 Sep - Oct
Vol. 5
Issue 5
Pg. 1264-1271
ISSN: 2213-2201 [Electronic] United States |
PMID | 28499778
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Allergens
- Ves v 5 allergen
- Wasp Venoms
- Immunoglobulin E
- Tryptases
- Epinephrine
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Topics |
- Adult
- Allergens
(immunology)
- Anaphylaxis
(diagnosis, epidemiology, therapy)
- Animals
- Desensitization, Immunologic
(methods)
- Epinephrine
(therapeutic use)
- Fatal Outcome
- Female
- Humans
- Immunoglobulin E
(blood)
- Insect Bites and Stings
(diagnosis, epidemiology)
- Male
- Mastocytosis, Systemic
(diagnosis, epidemiology, therapy)
- Middle Aged
- Risk
- Sensitivity and Specificity
- Tryptases
(blood)
- Urticaria Pigmentosa
- Wasp Venoms
(immunology)
- Wasps
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