Abstract | OBJECTIVE: METHODS: Human ovarian cancer cell lines and patients' ascites cells were treated with paclitaxel, cisplatin, and thiostrepton or a combination for 48 hours, and cytotoxicity was assessed. Drug combination effects were determined by calculating the combination index values using the Chou and Talalay method. Quantitative real-time polymerase chain reaction was performed to determine changes in FOXM1 expression and its downstream targets. RESULTS: CONCLUSION:
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Authors | Gina L Westhoff, Yi Chen, Nelson N H Teng |
Journal | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
(Int J Gynecol Cancer)
Vol. 27
Issue 5
Pg. 887-894
(06 2017)
ISSN: 1525-1438 [Electronic] England |
PMID | 28498253
(Publication Type: Journal Article)
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Chemical References |
- FOXM1 protein, human
- Forkhead Box Protein M1
- RNA, Messenger
- Platinum
- Thiostrepton
- Cisplatin
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(pharmacology)
- Ascites
(drug therapy, metabolism)
- Carcinoma, Ovarian Epithelial
- Cell Line, Tumor
- Cisplatin
(administration & dosage)
- Drug Resistance, Neoplasm
- Drug Synergism
- Female
- Forkhead Box Protein M1
(antagonists & inhibitors, biosynthesis, genetics)
- Humans
- Molecular Targeted Therapy
- Neoplasms, Glandular and Epithelial
(drug therapy, metabolism)
- Ovarian Neoplasms
(drug therapy, metabolism)
- Platinum
(administration & dosage)
- RNA, Messenger
(genetics, metabolism)
- Thiostrepton
(administration & dosage)
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