Abstract | BACKGROUND: OBJECTIVES: METHODS: We conducted a case-control study using Danish nationwide registry data. From the Cancer Registry (2004-2012), we identified 633 case patients with squamous cell carcinoma (SCC) of the lip and matched them to 63 067 population controls using a risk-set sampling strategy. Hydrochlorothiazide use (1995-2012) was obtained from the Prescription Registry and defined according to cumulative use. Applying conditional logistic regression, we calculated odds ratios ( ORs) for SCC lip cancer associated with hydrochlorothiazide use, adjusting for predefined potential confounders obtained from demographic, prescription and patient registries. RESULTS: Ever-use of hydrochlorothiazide was associated with an adjusted OR for SCC lip cancer of 2.1 (95% confidence interval (CI): 1.7-2.6), increasing to 3.9 (95%CI: 3.0-4.9) for high use (≥25 000 mg). There was a clear dose-response effect (P < 0.001), with the highest cumulative dose category of hydrochlorothiazide (≥100 000 mg) presenting an OR of 7.7 (95%CI: 5.7-10.5). No association with lip cancer was seen with use of other diuretics or nondiuretic antihypertensives. Assuming causality, we estimated that 11% of the SCC lip cancer cases could be attributed to hydrochlorothiazide use. CONCLUSIONS:
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Authors | A Pottegård, J Hallas, M Olesen, M T Svendsen, L A Habel, G D Friedman, S Friis |
Journal | Journal of internal medicine
(J Intern Med)
Vol. 282
Issue 4
Pg. 322-331
(10 2017)
ISSN: 1365-2796 [Electronic] England |
PMID | 28480532
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2017 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine. |
Chemical References |
- Diuretics
- Hydrochlorothiazide
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Topics |
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
(chemically induced, epidemiology)
- Case-Control Studies
- Denmark
(epidemiology)
- Diuretics
(adverse effects)
- Dose-Response Relationship, Drug
- Female
- Humans
- Hydrochlorothiazide
(adverse effects)
- Lip Neoplasms
(chemically induced, epidemiology)
- Logistic Models
- Male
- Middle Aged
- Registries
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