Abstract | INTRODUCTION: CASE REPORT: A 50-year-old Sri Lankan female with a previous history of 2 episodes of steroid-responsive ON presented with a 20/120 visual impairment of her right eye. On examination on admission, visual acuity was noted to be 20/30 on the left and visual evoked potentials were prolonged bilaterally, but all other neurological investigations including screening tests for infections and vasculitis were unremarkable. AQP4 antibodies were negative but MOG antibodies were positive. She responded to intravenous and long-term steroids combined with mycophenolate mofetil, but relapsed when steroids were discontinued. She has been relapse free on low-dose steroids and mycophenolate for 2 years. CONCLUSIONS: Recurrent ON occurs in association with MOG antibodies distinct from neuromyelitis optica and multiple sclerosis, and may require steroid-based immunosuppression to maintain remission. This case report from South Asia adds to map the worldwide occurrence of MOG antibody disease.
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Authors | Thashi Chang, Patrick Waters, Mark Woodhall, Angela Vincent |
Journal | The neurologist
(Neurologist)
Vol. 22
Issue 3
Pg. 101-102
(May 2017)
ISSN: 2331-2637 [Electronic] United States |
PMID | 28471902
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Autoantibodies
- Myelin-Oligodendrocyte Glycoprotein
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Topics |
- Autoantibodies
(blood, immunology)
- Female
- Humans
- Middle Aged
- Myelin-Oligodendrocyte Glycoprotein
(blood, immunology)
- Optic Neuritis
(immunology)
- Recurrence
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