Abstract | BACKGROUND: OBJECTIVE: METHOD: Sera were obtained from patients and evaluated by ELISA for IgG, IgA and IgM antibodies to SP1, CA6 and PSP. RESULTS:
IgA anti-CA6 antibodies were noted in 38% of these patients, but anti-SP1, CA6 and PSP IgM or IgG antibodies were identified only in a minority of patients. In patients with secondary SS, antibodies to SP1/CA6/PSP were more sensitive and specific than anti-Ro . CONCLUSION: While more studies are needed, antibodies to SP1, CA6 and PSP provide valuable markers for the diagnosis of primary and secondary SS, especially early in the course of the disease.
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Authors | Ellen De Langhe, Xavier Bossuyt, Long Shen, Kishore Malyavantham, Julian L Ambrus, Lakshmanan Suresh |
Journal | The open rheumatology journal
(Open Rheumatol J)
Vol. 11
Pg. 10-15
( 2017)
ISSN: 1874-3129 [Print] United Arab Emirates |
PMID | 28400867
(Publication Type: Journal Article)
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