Nuclear magnetic resonance studies on malignant fibrous histiocytoma--evaluation of the effectiveness of chemotherapy in anticancer drug.

Abstract	The relaxation times of water protons in the tissues of malignant fibrous histiocytoma (MFH) and the tumor treated with adriamycin (adriamycin-treated MFH) were studied in rats as a model of human MFH by nuclear magnetic resonance. Using the values of the malignancy index derived from the relaxation times of these tumors, it has been possible to discriminate clearly between MFH tissue and non-malignant tissue, and to evaluate the effectiveness of anticancer drug. The malignancy index, furthermore, was compatible with the histological evaluation of the effectiveness of chemotherapy in an adriamycin-treated malignant fibrous histiocytoma.
Authors	Y Shimomura, M Yamasaki
Journal	Nihon Seikeigeka Gakkai zasshi (Nihon Seikeigeka Gakkai Zasshi) Vol. 61 Issue 12 Pg. 1405-12 (Dec 1987) ISSN: 0021-5325 [Print] Japan
PMID	2836531 (Publication Type: Journal Article)
Chemical References	Doxorubicin
Topics	Animals Doxorubicin (therapeutic use) Drug Evaluation Histiocytoma, Benign Fibrous (drug therapy, pathology) Magnetic Resonance Spectroscopy Male Neoplasm Transplantation Rats Rats, Inbred Strains

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