Pterocarpan scaffold: A natural lead molecule with diverse pharmacological properties.

Abstract

Phytoalexins are substances produced by plants that act as potent inhibitors of pathogens. Pterocarpans are biologically active isoflavonoids most commonly found in the family Fabaceae that have the ability to act as phytoalexins. It is made up of a tetracyclic ring system possessing benzofuran-benzopyran. A very great number of pterocarpans have been isolated from natural sources and they are proved to have significant biological activities such as anti-microbial, anti-cancerous, anti-inflammatory and anti-malarial activities. Recently, pterocarpans gained lot of attention because of the broad range of anti-cancer activities in various cancer cell lines such as breast, leukemia, cervical, lung, colon and melanoma. Interestingly, pterocarpans exhibited inhibitory potency against many enzymes such as PTP1B, Neuraminidase, and α-glycosidase. In addition, they were shown to have anti-estrogenic and anti-diabetic activities. This review is a comprehensive inventory of the structures and sources of pterocarpans and it emphasizes on the biological evaluations of pterocarpans from various plant sources and their scope as a lead molecule.

• Authors: Chelliah Selvam, Brian C Jordan, Sandhya Prakash, Daniel Mutisya, Ramasamy Thilagavathi
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 128 Pg. 219-236 (Mar 10 2017) ISSN: 1768-3254 [Electronic] France
• PMID: 28189086 (Publication Type: Journal Article, Review)
• Copyright: Published by Elsevier Masson SAS.

Chemical References

• Anti-Infective Agents
• Anti-Inflammatory Agents
• Antimalarials
• Antineoplastic Agents
• Pterocarpans

Topics

• Anti-Infective Agents (pharmacology)
• Anti-Inflammatory Agents (pharmacology)
• Antimalarials (pharmacology)
• Antineoplastic Agents (pharmacology)
• Humans
• Pterocarpans (chemistry)