The Role of Chemotherapy in the Management of Sinonasal and Ventral Skull Base Malignancies.

Abstract

In most cases of advanced sinonasal and ventral skull base cancer, a multimodal treatment approach provides the best chance for improved outcomes. Depending on the tumor type and extent of disease, systemic chemotherapy has been shown to play an important role in neoadjuvant, concomitant, and adjuvant settings. The lack of randomized trials continues to limit its indications. Further high-quality studies are needed to understand ideal chemotherapeutic regimens and their role and sequential timing in sinonasal and ventral skull base cancer.

• Authors: George A Scangas, Jean Anderson Eloy, Derrick T Lin
• Journal: Otolaryngologic clinics of North America (Otolaryngol Clin North Am) Vol. 50 Issue 2 Pg. 433-441 (Apr 2017) ISSN: 1557-8259 [Electronic] United States
• PMID: 28160997 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Topics

• Chemotherapy, Adjuvant (methods)
• Humans
• Paranasal Sinus Neoplasms (pathology, therapy)
• Skull Base (pathology)
• Skull Base Neoplasms (pathology, therapy)