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Targeted sustained delivery of antineoplastic agent with multicomponent polylactide stereocomplex micelle.

Abstract
A c(RGDfC)-decorated polylactide stereocomplex micelle (cRGD-SCM) was prepared through the stereocomplex and hydrophobic interactions among 4-arm poly(ethylene glycol)-block-poly(D-lactide) (4-arm PEG-b-PDLA), methoxy poly(ethylene glycol)-block-poly(L-lactide) (mPEG-b-PLLA), and c(RGDfC)-poly(ethylene glycol)-block-poly(L-lactide) (cRGD-PEG-b-PLLA) for targeted treatment of αvβ3 integrin-positive C26 colon cancer. Doxorubicin (DOX), a model antitumor drug, was loaded into cRGD-SCM with a diameter of approximately 100nm, and the drug loading efficiency was 45.9wt.%. cRGD-SCM/DOX with a sustained release pattern exhibited prolonged circulation time, upregulated accumulation in tumor, enhanced tumor inhibition, and decreased side effects compared with free DOX and non-targeting SCM/DOX in vivo. More interestingly, the targeting ligand in the terminal of PEG can be easily replaced with other targeting groups according to the different types of malignancies. Therefore, the cRGD-decorated platform might be a promising targeted drug delivery system for personal chemotherapy clinically.
AuthorsKexin Shen, Di Li, Jingjing Guan, Jianxun Ding, Zhongtang Wang, Jingkai Gu, Tongjun Liu, Xuesi Chen
JournalNanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 13 Issue 3 Pg. 1279-1288 (04 2017) ISSN: 1549-9642 [Electronic] United States
PMID28064009 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2017 Elsevier Inc. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Delayed-Action Preparations
  • Micelles
  • Peptides, Cyclic
  • Polyesters
  • cyclic arginine-glycine-aspartic acid peptide
  • poly(lactide)
  • Doxorubicin
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, pharmacokinetics, therapeutic use)
  • Cell Line, Tumor
  • Colon (drug effects, pathology)
  • Colonic Neoplasms (drug therapy, pathology)
  • Delayed-Action Preparations (chemistry)
  • Doxorubicin (administration & dosage, pharmacokinetics, therapeutic use)
  • Drug Delivery Systems
  • Mice
  • Mice, Inbred BALB C
  • Micelles
  • Peptides, Cyclic (chemistry)
  • Polyesters (chemistry)

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