Gestational Hyperandrogenism in Developmental Programming.

Abstract

Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of reproductive age. The potential causes of androgen excess in women include polycystic ovary syndrome, congenital adrenal hyperplasia (CAH), adrenal tumors, and racial disparity among many others. During pregnancy, luteoma, placental aromatase deficiency, and fetal CAH are additional causes of gestational hyperandrogenism. The present report reviews the various phenotypes of hyperandrogenism during pregnancy and its origin, pathophysiology, and the effect of hyperandrogenism on the fetal developmental trajectory and offspring consequences.

• Authors: Christopher Hakim, Vasantha Padmanabhan, Arpita K Vyas
• Journal: Endocrinology (Endocrinology) Vol. 158 Issue 2 Pg. 199-212 (02 01 2017) ISSN: 1945-7170 [Electronic] United States
• PMID: 27967205 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2017 by the Endocrine Society.

Chemical References

• Androgens

Topics

• Androgens (physiology)
• Animals
• Female
• Fetal Development
• Humans
• Hyperandrogenism (etiology)
• Pregnancy
• Pregnancy Complications (etiology)