Abstract | BACKGROUND: METHODS: RESULTS: After 7 days of treatment, NPWT could obviously promote diabetic wound healing because of the mild inflammation and the dense cell-deposited matrix. Meanwhile, NPWT significantly decreased the expression of TNF-α, IL-6, and iNOS (all P < .05). The result of Western blotting and real-time PCR indicated that NPWT obviously decreased the level of Ik B-α and NF-κB p65, and increased the level of ATF-3 (all P < .05). CONCLUSION: NPWT exerts an anti-inflammatory effect, possibly through the suppression of proinflammatory enzymes and cytokines resulting from Ik B-α inhibition and ATF-3 activation, which may prevent the activation of the NF-κB pathway in human diabetic foot wounds.
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Authors | T Wang, R He, J Zhao, J C Mei, M Z Shao, Y Pan, J Zhang, H S Wu, M Yu, W C Yan, L M Liu, F Liu, W P Jia |
Journal | Diabetes/metabolism research and reviews
(Diabetes Metab Res Rev)
Vol. 33
Issue 4
(05 2017)
ISSN: 1520-7560 [Electronic] England |
PMID | 27883358
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 John Wiley & Sons, Ltd. |
Chemical References |
- ATF3 protein, human
- Activating Transcription Factor 3
- Interleukin-6
- NF-kappa B
- Tumor Necrosis Factor-alpha
- Nitric Oxide Synthase Type II
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Topics |
- Activating Transcription Factor 3
(metabolism)
- Aged
- Diabetic Foot
(metabolism, therapy)
- Down-Regulation
- Female
- Humans
- Inflammation
(metabolism, pathology, therapy)
- Interleukin-6
(metabolism)
- Male
- Middle Aged
- NF-kappa B
(metabolism)
- Negative-Pressure Wound Therapy
- Nitric Oxide Synthase Type II
(metabolism)
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(metabolism)
- Up-Regulation
- Wound Healing
(physiology)
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