Preventive Intra Oral Treatment of Sea Cucumber Ameliorate OVA-Induced Allergic Airway Inflammation.

Abstract

Sea cucumber extracts have potent biological effects, including anti-viral, anti-cancer, antibacterial, anti-oxidant, and anti-inflammation effects. To understand their anti-asthma effects, we induced allergic airway inflammation in mice after 7 oral administrations of the extract. The hyper-responsiveness value in mice with ovalbumin (OVA)-alum-induced asthma after oral injection of sea cucumber extracts was significantly lower than that in the OVA-alum-induced asthma group. In addition, the number of eosinophils in the lungs of asthma-induced mice pre-treated with sea cucumber extract was significantly decreased compared to that of PBS pre-treated mice. Additionally, CD4[Formula: see text]CD25[Formula: see text]Foxp3[Formula: see text]T (regulatory T; Treg) cells significantly increased in mesenteric lymph nodes after 7 administrations of the extract. These results suggest that sea cucumber extract can ameliorate allergic airway inflammation via Treg cell activation and recruitment to the lung.

• Authors: Da-In Lee, Mi-Kyung Park, Shin Ae Kang, Jun-Ho Choi, Seok-Jung Kang, Jeong-Yeol Lee, Hak Sun Yu
• Journal: The American journal of Chinese medicine (Am J Chin Med) Vol. 44 Issue 8 Pg. 1663-1674 ( 2016) ISSN: 1793-6853 [Electronic] Singapore
• PMID: 27852121 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Tissue Extracts
• Ovalbumin

Topics

• Administration, Oral
• Animals
• Anti-Inflammatory Agents
• Asthma (immunology, prevention & control)
• Disease Models, Animal
• Eosinophils (immunology)
• Female
• Lung (immunology)
• Lymph Nodes (immunology)
• Mice, Inbred C57BL
• Ovalbumin (immunology)
• Sea Cucumbers (chemistry)
• T-Lymphocytes, Regulatory (immunology)
• Tissue Extracts (administration & dosage, pharmacology)