Correlation between brain damage, associated biomarkers, and medication in psychiatric inpatients: A cross-sectional study.

Abstract

BACKGROUND:

We clarified the correlation between brain damage, associated biomarkers and medication in psychiatric patients, because patients with schizophrenia have an increased risk of stroke.

METHODS:

The cross-sectional study was performed from January 2013 to December 2015. Study participants were 96 hospitalized patients (41 men and 55 women) in the Department of Psychiatry at Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan. Patients were classified into schizophrenia (n=70) and mood disorders (n=26) by psychiatric diagnoses with DSM-IV-TR criteria.

RESULTS:

The incidence of brain damage [symptomatic and silent brain infarctions (SBIs) and white matter hyperintensity (WMH)] was correlated more with mood disorders than with schizophrenia. It has been previously shown that the concentrations of protein-conjugated acrolein (PC-Acro) and interleukin-6 (IL-6) increased in plasma of brain infarction patients together with C-reactive protein (CRP). The concentration of PC-Acro was significantly higher in patients with mood disorders than in those with schizophrenia. The concentration of IL-6 in both groups was nearly equal to that in the control group, but that of CRP in both groups, especially in mood disorders, was higher than that in the control group. Accordingly, the relative risk value for brain infarction was higher in patients with mood disorders than with schizophrenia. Medication with atypical antipsychotics reduced PC-Acro significantly in all psychiatric patients and reduced IL-6 in mood disorder patients.

CONCLUSION:

Measurement of 3 biomarkers (CRP, PC-Acro and IL-6) are probably useful for judgement of severity of brain damage and effectiveness of medication in psychiatric patients.

• Authors: Madoka Yoshida, Tetsuto Kanzaki, Mutsumi Mizoi, Mizuho Nakamura, Takeshi Uemura, Seisuke Mimori, Yoriyasu Uju, Keisuke Sekine, Yukihiro Ishii, Taro Yoshimi, Reiko Yasui, Asuka Yasukawa, Mamoru Sato, Seiko Okamoto, Tetsuya Hisaoka, Masafumi Miura, Shun Kusanishi, Kanako Murakami, Chieko Nakano, Yasuhiko Mizuta, Shunichi Mishima, Tatsuro Hayakawa, Kazumi Tsukada, Keiko Kashiwagi, Kazuei Igarashi
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 464 Pg. 50-56 (Jan 2017) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 27816667 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier B.V. All rights reserved.

Chemical References

• Antipsychotic Agents
• Biomarkers

Topics

• Adult
• Antipsychotic Agents (pharmacology, therapeutic use)
• Biomarkers (blood)
• Brain Infarction (complications)
• Brain Injuries (complications)
• Cross-Sectional Studies
• Female
• Humans
• Inpatients
• Male
• Middle Aged
• Mood Disorders (blood, complications, drug therapy)
• Schizophrenia (blood, complications, drug therapy)