A highly sensitive and selective electrochemical determination of non-steroidal prostate anti-cancer drug nilutamide based on f-MWCNT in tablet and human blood serum sample.

Abstract

A novel electrochemical sensor based on the functionalized multiwalled carbon nanotube (f-MWCNT) was successfully developed for the sensitive and selective determination of non-steroidal prostate anti-cancer drug nilutamide in tablet and blood serum samples. The f-MWCNT was prepared by the simple reflux method and characterized by the scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Raman spectroscopy, X-ray powder diffraction (XRD) and fourier transform infrared spectroscopy (FT-IR). Interestingly, the f-MWCNT was exhibited a superior electrocatalytic activity towards the anti-cancer drug nilutamide when compared with pristine MWCNT and unmodified electrodes. Besides, the electrochemical sensor was revealed an excellent current response for the determination of nilutamide with wide linear ranges (0.01-21μM and 28-535μM), high sensitivity (11.023 and 1.412μA μM-1cm2) and very low detection limit (LOD) 0.2nM. The developed electrochemical sensor was showed an excellent selectivity even in the presence of electrochemically active biological substances and nitro aromatic compounds. Moreover, it manifested a good reproducibility and stability. In addition, the f-MWCNT modified glassy carbon electrode (GCE) sensor was successfully applied for the detection of nilutamide in tablet and blood serum sample.

• Authors: R Karthik, R Sasikumar, Shen-Ming Chen, J Vinoth Kumar, A Elangovan, V Muthuraj, P Muthukrishnan, Fahad M A Al-Hemaid, M Ajmal Ali, Mohamed S Elshikh
• Journal: Journal of colloid and interface science (J Colloid Interface Sci) Vol. 487 Pg. 289-296 (Feb 01 2017) ISSN: 1095-7103 [Electronic] United States
• PMID: 27792936 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Androgen Antagonists
• Antineoplastic Agents
• Imidazolidines
• Nanotubes, Carbon
• Tablets
• nilutamide

Topics

• Androgen Antagonists (blood)
• Antineoplastic Agents (blood)
• Biosensing Techniques
• Electrochemical Techniques
• Electrodes
• Humans
• Imidazolidines (blood)
• Limit of Detection
• Nanotubes, Carbon (chemistry, ultrastructure)
• Reproducibility of Results
• Tablets